In September of 1888 he began a service of twenty-seven years as national secretary of the Intercollegiate Y.M.C.A. of the U.S.A. and Canada, a position requiring visits to colleges to address students concerning Christian activities.
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The sum of Mott's work makes an impressive record: he wrote sixteen books in his chosen field; crossed the Atlantic over one hundred times and the Pacific fourteen times, averaging thirty-four days on the ocean per year for fifty years; delivered thousands of speeches; chaired innumerable conferences, and received dozens of awards. At 81, the Nobel committee awarded him one of the highest honors given on earth - the Nobel Peace Prize. He died at his home in Orlando, Florida at the age of eighty-nine.